Molecules 2015-01-01

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols.

Ana L Legarda-Ceballos, Esther del Olmo, Julio López-Abán, Ricardo Escarcena, Luis A Bustos, Cristina Fonseca-Berzal, Alicia Gómez-Barrio, Juan C Dib, Arturo San Feliciano, Antonio Muro

Index: Molecules 20 , 11554-68, (2015)

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Abstract

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.