Hemin

Modify Date: 2024-01-02 12:25:39

Hemin Structure
Hemin structure
 Common Name Hemin
CAS Number 16009-13-5 Molecular Weight 651.940
Density N/A Boiling Point N/A
Molecular Formula C34H32ClFeN4O4 Melting Point 300 °C
MSDS Chinese USA Flash Point N/A

 Use of Hemin


Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.

 Names

Name hemin
Synonym More Synonyms

 Hemin Biological Activity

Description Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
Related Catalog
Target

Heme oxygenase[1]

In Vitro Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment[1].
In Vivo Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning[2].
Cell Assay For the cell proliferation assay, cells are seeded into 96 well (5-12.5×104 cells per mL according to the cell line) and kept at 37°C and 5 % CO2. After 24 h, cells are treated with statins or/and Hemin, followed by the MTT test as a general cell proliferation assay[1].
Animal Admin Mice[2] Eight- to ten-week-old male BABL/c mice are used for the ischemia-reperfusion (I/R) experiments. The animals are divided into five groups as follows: (1) the sham group undergo isolation of the bilateral renal arteries without clamping; (2) the vehicle group receive an intraperitoneal (i.p.) injection of 4 mL/kg PBS as a vehicle control (with IRI); (3) the Hemin-preconditioned group receive Hemin, a potent inducer of HO-1, at 100 μmol/kg i.p.; (4) the Hemin plus ZnPP group receive zinc protoporphyrin IX, an inhibitor of HO-1 activity, at 5 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p.; and (5) the Hemin plus PD98059 group receive PD98059, an inhibitor of ERK1/2 activity, at 10 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p. Both inhibitors are administered i.p. 2 h before I/R, whereas Hemin was administered 8 h before I/R.
References

[1]. Vanova K, et al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells. BMC Cancer. 2016 May 12;16:309.

[2]. Chen HH, et al. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2195-201.

 Chemical & Physical Properties

Melting Point 300 °C
Molecular Formula C34H32ClFeN4O4
Molecular Weight 651.940
Exact Mass 651.146179
PSA 109.18000
LogP 4.29920
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents. Combustible.

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes N,Xi
Risk Phrases R10:Flammable. R19:May form explosive peroxides. R50:Very Toxic to aquatic organisms. R36:Irritating to the eyes.
Safety Phrases 24/25-22-36-26
RIDADR UN 3272 3/PG 3
WGK Germany 3
RTECS LJ8080000
Packaging Group III
Hazard Class 3

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 Synonyms

Iron, chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]-
Hemin
Chloro(protoporphyrinato)iron(III)
MFCD00010726
Chloro[3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]iron
Ferriprotoporphyrin chloride
7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid
Ferriheme chloride
Ferriprotoporphyrin IX chloride
Chloroprotoporphyrin IX iron(III)
EINECS 240-140-1
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