Biochemical Pharmacology 2012-01-01

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

Grazia Graziani, Simona Artuso, Anastasia De Luca, Alessia Muzi, Dante Rotili, Manuel Scimeca, Maria Grazia Atzori, Claudia Ceci, Antonello Mai, Carlo Leonetti, Lauretta Levati, Elena Bonanno, Lucio Tentori, Anna Maria Caccuri

Index: Biochem. Pharmacol. 95 , 16-27, (2015)

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Abstract

Nitrobenzoxadiazoles exert antitumor effects against vemurafenib-resistant melanoma cells by sustained activation of different MAPK pathways.