Eksperimental'naia i klinicheskaia farmakologiia 2010-10-01

[Pharmacological correction of the cytogenetic effects of cisplatin].

O L Voronova, O V Neupokoeva, E P Fedorova, A E Prosenko, A A Churin

Index: Eksp. Klin. Farmakol. 73(10) , 37-9, (2010)

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Abstract

Beginning with the first hours of experiments, cisplatin evoked an increase of chromosomal aberrations in CBA/CaLac bone marrow cells. Significant increase of structural infringements of chromosomes due to chromatid breaks was revealed in metaphase plates of murine bone marrow preparations through 24 h after cisplatin intraperitoneal introduction. In late terms of research (90th day), the high level of aberrations of chromosomes was retained. The most pronounced correction of cisplatin mutagenicity was achieved using a preliminary course of thiophan introduction.