International Journal of Cosmetic Science 2015-08-01

β-cyclodextrin in personal care formulations: role on the complexation of malodours causing molecules.

A Lopedota, A Cutrignelli, V Laquintana, M Franco, D Donelli, L Ragni, S Tongiani, N Denora

Index: Int. J. Cosmet. Sci. 37 , 438-45, (2015)

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Abstract

The aim of this study was to prove the capability of β-cyclodextrin (β-CD) to interact with some representative molecules responsible to cause body malodour, such as carboxylic acids, thiols and steroids, present in sweat and body secretions.The association constants in guest-CD were determined by (1) H-NMR spectroscopy for thiols and steroids such as 3-mercapto-1-hexanol, androstenone, androstenol and androsterone, and pH-potentiometric titration for acetic acid, l(+) lactic acid, isobutyric acid, isovaleric acid and 3-hydroxy-3-methyl-hexanoic acid.All considered systems are able to interact with relatively weak association constants with β-cyclodextrin, in a 1 : 1 host-guest ratio.From these findings, it is possible to conclude that β-CD is capable to interact with different components present in the sweat and body secretion, forming inclusion complexes. For this reason, β-CD could be a component of body care formulations, such as deodorants.© 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.