3, 5-Bis (trifluoromethyl) phenyl sulfones in the direct Julia-Kocienski olefination

DA Alonso, M Fuensanta, C Nájera…

Index: Alonso, Diego A.; Fuensanta, Monica; Najera, Carmen; Varea, Montserrat Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6404 - 6416

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Citation Number: 53

Abstract

3, 5-Bis (trifluoromethyl) phenyl (BTFP) sulfones 7 have been employed in the Julia- Kocienski olefination reaction with carbonyl compounds. Sulfones 7 are readily prepared in high yields (64-97%) from commercially available 3, 5-bis (trifluoromethyl) thiophenol through an alkylation/oxidation two-step sequence. The stability of metalated BTFP sulfones has been studied and compared with heteroaryl benzothiazol-2-yl (BT), 1-phenyl-1 H- ...