Anticancer Research 2015-01-01

KML001 enhances anticancer activity of gemcitabine against pancreatic cancer cells.

Moon Hee Yang, Kyu Taek Lee, Sera Yang, Jong Kyoon Lee, Kwang Hyuck Lee, Jong Chul Rhee

Index: Anticancer Res. 35(1) , 183-9, (2015)

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Abstract

Gemcitabine is a drug commonly used to treat pancreatic cancer but chemoresistance to it is a common clinical issue. KML001 (sodium meta-arsenite) has demonstrated certain antitumor activity. The objective of the study was to evaluate the influence of KML001 on the anticancer activity of gemcitabine against pancreatic cancer cells.Cell proliferation, migration, and invasion were assessed, as well as the expression of nuclear factor-kappa B (NF-κB) p65, epidermal growth factor receptor (EGFR), matrix metalloproteinase-2 (MMP2), and vascular endothelial growth factor-C (VEGFC) in pancreatic cancer cells.Treatment with a combination of KML001 and gemcitabine resulted in significant inhibition of cell proliferation, migration, and invasion, and significantly reduced EGFR and MMP2 expression compared to gemcitabine treatment-alone.Combination treatment of gemcitabine and KML001 could be an effective chemotherapeutic treatment for pancreatic cancer.Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.