2'-Deoxycytidine monohydrate
2'-Deoxycytidine monohydrate structure
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Common Name | 2'-Deoxycytidine monohydrate | ||
|---|---|---|---|---|
| CAS Number | 951-77-9 | Molecular Weight | 227.22 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 482.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H13N3O4 | Melting Point | 209-211 °C(lit.) | |
| MSDS | USA | Flash Point | 245.4±31.5 °C | |
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Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.
Anal. Bioanal. Chem 407(13) , 3693-704, (2015) Nucleosides and nucleoside triphosphates are the building blocks of nucleic acids and important bioactive metabolites, existing in all living cells. In the present study, two liquid chromatography tandem mass spectrometry methods were developed to quantify bo... |
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Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.
J. Chromatogr. A. 1356 , 197-210, (2014) Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved understanding of the absorption and intermediary metabolism ... |
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Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.
Bioorg. Med. Chem. 16 , 3866-70, (2008) Thymidine phosphorylase (TP, EC 2.4.2.4) recognized the structure of the substrate with high specificity, via both the base and the ribosyl moieties. The replacement of 3'-OH of thymidine markedly influenced its catalytic activity with TP. The conversion of p... |
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Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
Bioorg. Med. Chem. Lett. 20 , 841-3, (2010) We are reporting on the synthesis of fluorescent nucleoside analogs with modified sugar moieties (e.g., sugars other than ribose and 2'-deoxyribose). Four novel derivatives of the fluorescent thymidine analog 6-methyl-3-(beta-D-2'-deoxyribofuranosyl) furano-[... |
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Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine.
Biochim. Biophys. Acta 1853(1) , 89-100, (2015) Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths worldwide; PDAC is characterized by poor prognosis, resistance to conventional chemotherapy and high mortality rate. TP53 tumor suppressor gene is frequently mutated in PDAC... |
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Ultrasensitive UPLC-MS/MS method for analysis of etheno-DNA adducts in human white blood cells.
Free Radic. Res. 49 , 1049-54, (2015) Etheno-DNA adducts are generated by interaction of cellular DNA with exogenous environmental carcinogens and end products of lipid peroxidation. It has been determined that 1,N(6)-etheno-2'-deoxyadenosine (εdA) and 3,N(4)-etheno-2'-deoxycytidine (εdC) adducts... |
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Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme.
Eur. J. Cancer 50(18) , 3125-35, (2014) Since sorafenib has shown activity in different tumour types and gemcitabine regimens improved the outcome for biliary tract cancer (BTC) patients, we evaluated first-line gemcitabine plus sorafenib in a double-blind phase II study.102 unresectable or metasta... |
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Validation of a hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of gemcitabine in human plasma with tetrahydrouridine.
Biomed. Chromatogr. 29 , 1343-9, (2015) A simple and reproducible bioanalytical method for the determination of gemcitabine in human plasma treated with tetrahydrouridine (THU) was developed and validated using a hydrophilic interaction ultra-performance liquid chromatography with tandem mass spect... |
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KML001 enhances anticancer activity of gemcitabine against pancreatic cancer cells.
Anticancer Res. 35(1) , 183-9, (2015) Gemcitabine is a drug commonly used to treat pancreatic cancer but chemoresistance to it is a common clinical issue. KML001 (sodium meta-arsenite) has demonstrated certain antitumor activity. The objective of the study was to evaluate the influence of KML001 ... |
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Simvastatin plus capecitabine–cisplatin versus placebo plus capecitabine–cisplatin in patients with previously untreated advanced gastric cancer: A double-blind randomised phase 3 study
Eur. J. Cancer 50(16) , 2822-30, (2014) Purpose We aimed to the addition of synthetic 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitor, simvastatin to capecitabine–cisplatin (XP) in patients with previously untreated advanced gastric cancer (AGC). |