Bioorganic & Medicinal Chemistry Letters 2007-11-15

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl

Index: Bioorg. Med. Chem. Lett. 17(22) , 6206-11, (2007)

Full Text: HTML

Abstract

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

Related Compounds

Structure Name/CAS No. Articles
5-Bromo-2,4-dichloropyrimidine Structure 5-Bromo-2,4-dichloropyrimidine
CAS:36082-50-5