Archives of Pharmacal Research 2012-05-01

New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.

Seung Ill Kim, Seung Ho Lee, Eung-Seok Lee, Chong-Soon Lee, Yurngdong Jahng

Index: Arch. Pharm. Res. 35(5) , 785-9, (2012)

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Abstract

A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.