Rutaecarpine
Rutaecarpine structure
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Common Name | Rutaecarpine | ||
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| CAS Number | 84-26-4 | Molecular Weight | 287.315 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 550.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H13N3O | Melting Point | 259.5 - 260ºC | |
| MSDS | Chinese USA | Flash Point | 286.5±32.9 °C | |
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Pharmacological effects of rutaecarpine as a cardiovascular protective agent.
Molecules 15(3) , 1873-81, (2010) Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa ('Wu-Chu-Yu') remains the most popular and multi-purpose herb traditionally used in China for treatment of headac... |
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Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
Fitoterapia 83(5) , 954-60, (2012) Evodiamine (EVO) and rutaecapine (RUT), the major active components from Evodia rutaecarpa extract (EE), are recognized as a depended analgesic agent. This study was designed to investigate the effect of purity and chemical enhancers on the transdermal behavi... |
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Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
Arch. Pharm. Res. 34(1) , 119-25, (2011) Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this phenomenon is unclear. We investigated the microsomal enzyme activity using... |
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Synthesis and biological properties of benzo-annulated rutaecarpines.
Biol. Pharm. Bull. 33(10) , 1704-9, (2010) A series of benzo-annulated rutaecarpines were prepared from anthranilic acid and 3-aminonaphthalene-2-carboxylic acid by Fischer indole synthesis as key reaction. Cytotoxicity was somewhat increased by the introduction of benzo-annulation, which was not dire... |
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Rutaecarpine prevents hypoxia-reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases.
Can. J. Physiol. Pharmacol. 89(3) , 177-86, (2011) It is proposed that myocardial cell apoptosis causes ventricular remodeling and heart failure. The aim of the present study was to determine the effects of rutaecarpine (Rut) on hypoxia-reoxygenation (H-R)-induced apoptosis in myocardial cell line H9c2, as we... |
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A new quinolone and other constituents from the fruits of Tetradium ruticarpum: effects on neutrophil pro-inflammatory responses.
Chem. Biodivers. 7(7) , 1828-34, (2010) The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9-dienyl]quinolin-4(1H)-one (1),... |
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Reversal of isoprenaline-induced cardiac remodeling by rutaecarpine via stimulation of calcitonin gene-related peptide production.
Can. J. Physiol. Pharmacol. 88(10) , 949-59, (2010) Dysfunction of capsaicin-sensitive sensory nerves is involved in cardiac remodeling, and rutaecarpine has been shown to exert a beneficial effect on cardiac function through activating the sensory nerves. This study was conducted to explore the potential inhi... |
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New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.
Arch. Pharm. Res. 35(5) , 785-9, (2012) A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed stro... |
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Simultaneous determination and pharmacokinetic analysis of seven alkaloids and two flavonoids from rat plasma by HPLC-DAD after oral administration of Wuzhuyu decoction.
J. Asian Nat. Prod. Res. 14(4) , 370-81, (2012) A simple and sensitive high-performance liquid chromatographic method was developed for the simultaneous determination and pharmacokinetic analysis of seven alkaloids dehydroevodiamine (DHED), 10-hydroxyrutaecarpine (HDR), evodiamine (EDM), rutaecarpine (RCP)... |
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New glycosidic alkaloid from the nearly ripe fruits of Euodia rutaecarpa.
J. Asian Nat. Prod. Res. 14(7) , 634-9, (2012) A new natural product, 10-hydroxyrutaecarpine (1), and a rarely new glycosidic alkaloid, rutaecarpine-10-O-rutinoside (2), along with the known compounds rutaecarpine (3), evodiamine, wuzhuyuamide-I, and dehydroevodiamine were isolated from the butanol fracti... |