Chemical Communications 2003-06-07

Improved biotransformations on charged PEGA supports.

Alessandra Basso, Luigi De Martin, Lucia Gardossi, Graham Margetts, Ian Brazendale, Annie Y Bosma, Rein V Ulijn, Sabine L Flitsch

Index: Chem. Commun. (Camb.) (11) , 1296-7, (2003)

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Abstract

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.