Bioorganic & Medicinal Chemistry Letters 2002-07-22

A solid-supported phosphine-free ruthenium alkylidene for olefin metathesis in methanol and water.

Stephen J Connon, Siegfried Blechert

Index: Bioorg. Med. Chem. Lett. 12(14) , 1873-6, (2002)

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Abstract

The synthesis and olefin metathesis activity in protic solvents of 7, a phosphine-free ruthenium alkylidene bound to a hydrophilic solid support are reported. This heterogeneous catalyst promotes relatively efficient ring closing- and cross-metathesis reactions in both methanol and water. The potential utility of homogeneous catalyst 2 for olefin metathesis in methanol is also demonstrated.