On the preparation of aryl nitriles using tosyl cyanide

KJ Rutan, FJ Heldrich, LF Borges

Index: Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F. Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950

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Citation Number: 16

Abstract

As part of our investigation into the preparation of retrograde axonally transported fluorescent-imaging agents1 (RATFIA), we desired an expedient method to convert aryl halides into benzonitriles. 2 The classic method is the Rosenmund synthesis which is not universally applicable because it requires empirical derivation of a unique set of reaction times and temperatures and solvents for each~ ubstrate.~ More recent reports have dealt ...