Metabolism of tamoxifen by isolated rat hepatocytes: Identification of the glucuronide of 4-hydroxytamoxifen

R McCague, IB Parr, G Leclercq, OT Leung…

Index: McCague, Raymond Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793

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Citation Number: 31

Abstract

Abstract Metabolism of 4-hydroxytamoxifen by hepatocytes isolated from rats administered with phenobarbital and examination by TLC of the components not extractable into ethyl acetate revealed 4-hydroxytamoxifen β-glucuronide; its identity was confirmed by