Organic Letters 2010-11-19

General and mild preparation of 2-aminopyridines.

Allyn T Londregan, Sandra Jennings, Liuqing Wei

Index: Org. Lett. 12(22) , 5254-7, (2010)

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Abstract

A general and facile one-pot amination procedure for the synthesis of 2-aminopyridines from the corresponding pyridine-N-oxides is presented as a mild alternative to S(N)Ar chemistry. A variety of amines and heterocyclic-N-oxides participate effectively in this transformation which uses the phosphonium salt, PyBroP, as a means of substrate activation.