Development of Vizantin, a Safe Immunostimulant, Based on the Structure–Activity Relationship of Trehalose-6, 6′-dicorynomycolate

…, H Imagawa, M Nagahama, S Himeno…

Index: Yamamoto, Hirofumi; Oda, Masataka; Nakano, Mayo; Watanabe, Naoyuki; Yabiku, Kenta; Shibutani, Masahiro; Inoue, Masahisa; Imagawa, Hiroshi; Nagahama, Masahiro; Himeno, Seiichiro; Setsu, Kojun; Sakurai, Jun; Nishizawa, Mugio Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 381 - 385

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Citation Number: 5

Abstract

Vizantin, 6, 6′-bis-O-(3-nonyldodecanoyl)-α, α′-trehalose, was developed as a safe immunostimulator on the basis of a structure–activity relationship (SAR) study with trehalose 6, 6′-dicorynomycolate (TDCM). It was possible to synthesize vizantin on a large scale more easily than in the case of TDCM, and the compound exhibited more potent prophylactic effect on experimental lung metastasis of B16–F0 melanoma cells. Because ...