European Journal of Medicinal Chemistry 2011-08-01

Synthesis and antimicrobial evaluation of new benzofuran derivatives.

Xizhen Jiang, Wenlu Liu, Wei Zhang, Faqin Jiang, Zhe Gao, Hao Zhuang, Lei Fu, Xizhen Jiang, Wenlu Liu, Wei Zhang, Faqin Jiang, Zhe Gao, Hao Zhuang, Lei Fu, Xizhen Jiang, Wenlu Liu, Wei Zhang, Faqin Jiang, Zhe Gao, Hao Zhuang, Lei Fu

Index: Eur. J. Med. Chem. 46 , 3526-30, (2011)

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Abstract

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S.aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC(80) = 0.39-3.12 μg/mL), which were better than the control drugs.Copyright © 2011 Elsevier Masson SAS. All rights reserved.