Resveratrol

Modify Date: 2024-01-02 11:39:33

Resveratrol Structure
Resveratrol structure
 Common Name Resveratrol
CAS Number 501-36-0 Molecular Weight 228.243
Density 1.4±0.1 g/cm3 Boiling Point 449.1±14.0 °C at 760 mmHg
Molecular Formula C14H12O3 Melting Point 253-255°C
MSDS Chinese USA Flash Point 222.3±14.7 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Resveratrol


Resveratrol (SRT 501), a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has a wide spectrum of targets including mTOR, JAK, β-amyloid.

 Names

Name Resveratrol
Synonym More Synonyms

 Resveratrol Biological Activity

Description Resveratrol (SRT 501), a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has a wide spectrum of targets including mTOR, JAK, β-amyloid.
Related Catalog
Target

IKKβ:1 μM (IC50)

Autophagy

Mitophagy

In Vitro Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported. Resveratrol also is a sirtuin activator[1]. MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled every 30 hr. Trypan blue exclusion assay shows that at concentrations of 10 μM or lower, Resveratrol does not affect cell viability (90% viable cells) whereas at 100 μM, only 50% of the cells are viable after 6 days of Resveratrol treatment. Moreover, MCF-7 cells do not undergo apoptosis after incubation with Resveratrol at concentration of 10 μM as determined by ApoAlert Annexin V Apoptosis kit[2].
In Vivo The average tumor volume is reduced by treatment with Resveratrol at a dose of 50 mg/kg body weight (195.5±124.8 mm3; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm3; P<0.001) compare with the vehicle-treated animals (315±94 mm3). There is a good correlation between the tumor volume and the tumor mass[3].
Cell Assay To determine the effect of Resveratrol on cell growth, MCF-7 cells are plated in 6-well plates at 105 cells per well in 2 mL of DME-F12 medium supplemented with 5% FBS in the presence or absence of increasing concentrations of Resveratrol. The cell number is measured every 2 days till day 6 with a hemocytometer after detaching the cells with trypsin-EDTA[2].
Animal Admin Mice[3] Female BALB/c (nu/nu) mice, 6 weeks old, are used. PA-1 cells (1×107 in 200 μL PBS) are injected s.c. on the right hind flank. Tumor volume (length×width×depth×0.52) is measured three times a week. After 10 days of implantation, two groups (n=10) are given Resveratrol (dissolved in 5% ethanol and 25% polyethyleneglycol 400 in distilled water) i.p. at a daily dose of 50 or 100 mg/kg body weight for consecutive 4 weeks, whereas the other group receive the vehicle only. Body weights are recorded everyday. Animals are given bromodeoxyuridine (BrdUrd; 10 mg/kg body weight, i.p.) 2 h before sacrifice. Xenograft tumors are weighed and frozen in liquid nitrogen or fixed in 10% formalin and embedded in paraffin. The BrdUrd-labeled cells in paraffin-embedded tissues are detected employing a monoclonal anti-BrdUrd antibody.
References

[1]. Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32

[2]. Lu R, et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304.

[3]. Lee MH, et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69(18):7449-58.

[4]. LI Ying, et al. Prevention of resveratrol on spatial memory loss of mice induced by calyculin A. Chin J Pathophysiol, 2017, 33(5): 951-955.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 449.1±14.0 °C at 760 mmHg
Melting Point 253-255°C
Molecular Formula C14H12O3
Molecular Weight 228.243
Flash Point 222.3±14.7 °C
Exact Mass 228.078644
PSA 60.69000
LogP 3.14
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.763
Storage condition −20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R37/38;R41
Safety Phrases S26-S39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CZ8987000
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

 Articles493

More Articles
Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.

Sci. Rep. 4 , 5896, (2014)

Dysfunctions of the mitochondria and the ubiquitin-proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the...

Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro.

Climacteric 17(6) , 682-91, (2014)

To explore the effect and pathway of phytoestrogens in vitro on the growth of both normal and malignant breast cells.Normal breast MCF-10A cells and breast cancer MCF-7 cells were incubated with 10 (-...

Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation.

Biochem. Pharmacol. 90(3) , 288-96, (2014)

Inhibition of 17α-hydroxylase/17,20-lyase (CYP17), which dictates the proceeding of androgen biosynthesis, is recommended as an effective treatment for androgen-dependent diseases. However, androgen d...

 Synonyms

5-[(E)-2-(4-Hydroxyphenyl)ethenyl]benzol-1,3-diol
1,3-Benzenediol, 5-[(E)-2-(4-hydroxyphenyl)ethenyl]-
RESVERTROL
MFCD00133799
3',4,5'-trihydroxy-trans-stilbene
1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-
3,4',5-Trihydroxy-trans-stilbene
(E)-5-(p-Hydroxystyryl)resorcinol
trans-3,5,4'-trihydroxy-stilbene
5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
(E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzendiol
3,5,4'-Trihydroxy-trans-stilbene
5-[(E)-2-(4-Hydroxyphenyl)vinyl]benzene-1,3-diol
RESVERATROLE
3,4',5-trihydroxy-stilbene
Resveratrol
TRANS-RESVERATROL
5-[(E)-2-(4-Hydroxyphenyl)vinyl]-1,3-benzenediol
5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene
(E)-5-(4-hydroxystyryl)benzene-1,3-diol
5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
EINECS 610-504-8
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Resveratrol suppliers

Price: ￥390/250mg

Reference only. check more Resveratrol price

Related Compounds: More...
resveratrol
823804-66-6
Resveratrol
61434-67-1
resveratrolPi
807311-20-2
Azo-Resveratrol
1393556-48-3
Resveratroloside
38963-95-0
Resveratrol-13C6
1185247-70-4
trans-resveratrol
145356-39-4
Dihydroresveratrol
151363-17-6
Dihydroresveratrol
58436-28-5
2-[3-(Pyridin-2-yloxy)phenoxy]acetic acid
950028-97-4
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
2-Methyl-1,2,3,4-tetrahydroisoquinolin-4-amine dihydrochloride
108276-73-9
tert-Butyl-DL-alanine
1375289-11-4
Chemsrc provides Resveratrol(CAS#:501-36-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Resveratrol are included as well.>> amp version: Resveratrol

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved