Journal of Natural Products 2000-08-01

A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens.

D E Wedge, D G Nagle

Index: J. Nat. Prod. 63(8) , 1050-4, (2000)

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Abstract

A new bioassay has been developed combining the simplicity of direct bioautography with the improved chromatographic resolution of 2D-TLC. Mixtures of structurally diverse antifungal agents were tested to establish the validity and utility of this method in the discovery of new natural products with activity against agriculturally important fungal pathogens.