Journal of Asian Natural Products Research 2007-01-01

Microbial transformation of curcumol by Cunninghamella blakesleana.

H Zhang, F Qiu, X-S Yao, G-X Qu

Index: J. Asian Nat. Prod. Res. 9(3-5) , 311-9, (2007)

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Abstract

Microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS 3.970) yielded six metabolites. On the basis of spectral data, their structures were elucidated as 14-hydroxy-9E curcumol (2), 10R,14-dihydroxy curcumol (3), 10S,14-epoxy curcumol (4), 10R,14-epoxy curcumol (5), 10S,14-epoxy-7,11-dehydrocurcumol (6), 10R,14-epoxy-7,11-dehydrocurcumol (7), respectively. Among them 2, 3, 6 and 7 are new compounds; 4 and 5, 6 and 7 are two pairs of epimers.