Curcumol
Curcumol structure
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Common Name | Curcumol | ||
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| CAS Number | 4871-97-0 | Molecular Weight | 236.350 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 334.5±42.0 °C at 760 mmHg | |
| Molecular Formula | C15H24O2 | Melting Point | 141-142ºC | |
| MSDS | USA | Flash Point | 134.7±22.1 °C | |
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Isolation and identification of phase 1 metabolites of curcumol in rats.
Drug Metab. Dispos. 38(11) , 2014-22, (2010) Curcumol is one of the major components of the essential oil of Curcuma wenyujin with the structure of a guaiane-type sesquiterpenoid hemiketal. It exhibits clear antitumor, antihepatic fibrosis, antioxidant, and antimicrobial activities. In this article, the... |
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Subunit-specific inhibition of glycine receptors by curcumol.
J. Pharmacol. Exp. Ther. 343(2) , 371-9, (2012) Emerging evidence has suggested that inhibitory glycine receptors (GlyRs) are an important molecular target in the treatment of numerous neurological disorders. Rhizoma curcumae is a medicinal plant with positive neurological effects. In this study, we showed... |
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Chemical constituents from the radix of Curcuma wenyujin.
Fitoterapia 80(6) , 374-6, (2009) Phytochemical study on the ethanol extract of the radixes of Curcuma wenyujin Y. H. Chen et C. Ling led to the isolation of three new compounds curcuminol F (1) curcuminol G (2) and wenyujinoside (3) and a known compound aurantiamide (4). Their structures wer... |
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Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells.
Med. Oncol. 28(1) , 307-14, (2011) Curcumol isolated from Rhizoma Curcumae, a common traditional Chinese medicine, has been reported to possess antitumor effects, but little is known about the molecular mechanism. The current study tried to explore the molecular mechanism of curcumol-induced c... |
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Microbial transformation of curcumol by Cunninghamella blakesleana.
J. Asian Nat. Prod. Res. 9(3-5) , 311-9, (2007) Microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS 3.970) yielded six metabolites. On the basis of spectral data, their structures were elucidated as 14-hydroxy-9E curcumol (2), 10R,14-dihydroxy curcumol (3), 10S,14-epoxy curcumol (4),... |
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Four novel metabolites from microbial transformation of curcumol by Cunninghamella blakesleana.
Chem. Pharm. Bull. 55(3) , 451-4, (2007) Further study on the microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS3.970) led to the isolation of four novel metabolites. Their structures were elucidated as 3beta-hydroxy curcumol (2), 12-hydroxy curcumol (3), 1alpha-hydroxy-10bet... |
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Microbial transformation of curcumol by Aspergillus niger.
Nat. Prod. Commun. 8(2) , 149-52, (2013) Curcumol is a representative index component for the quality control of the essential oil of Curcuma wenyujin Y.H. Chen et C. Ling, an antivirus and anticancer drug in China. Microbial transformation of curcumol (1) by Aspergillus niger AS 3.739 yielded two p... |
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Determination of curcumol in rat plasma by capillary gas chromatography with a hydrogen flame ionization detector.
Biomed. Chromatogr. 24(4) , 347-50, (2010) A simple and sensitive capillary gas chromatography with a hydrogen flame ionization detector (GC-FID) method was developed for the determination of curcumol in rat plasma. From a variety of compounds and solvents tested, buagafuran was selected as the intern... |
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Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil.
Z. Naturforsch., C, J. Biosci. 61(1-2) , 6-10, (2006) This work describes the seasonal variation of curcumenol (1) and dihydrocurdione (2), two active terpenoids from different parts (roots, mother rhizome and rugous rhizome) of Curcuma zedoaria grown in Brazil. The analysis was carried out by high resolution ga... |
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The absolute stereostructure of curcumol isolated from Curcuma wenyujin.
Chem. Pharm. Bull. 32(9) , 3783-6, (1984)
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