Chemical & Pharmaceutical Bulletin 2007-03-01

Four novel metabolites from microbial transformation of curcumol by Cunninghamella blakesleana.

Hui Zhang, Ning Kang, Feng Qiu, Ge-Xia Qu, Xin-Sheng Yao

Index: Chem. Pharm. Bull. 55(3) , 451-4, (2007)

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Abstract

Further study on the microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS3.970) led to the isolation of four novel metabolites. Their structures were elucidated as 3beta-hydroxy curcumol (2), 12-hydroxy curcumol (3), 1alpha-hydroxy-10beta,14-epoxy curcumol (4) and (2S,4S,5S,7S)-10-hydroxymethyl-7-isopropyl-2-methoxy-4-methyl-1-oxaspiro[4,6]undec-10-en-8-one (5) on the basis of spectral methods. All of them were characterized as new compounds.