European Journal of Medicinal Chemistry 2007-03-01

alpha-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents.

Preeti Sharma, Sangeeta Singh, Tanveer I Siddiqui, Vishnu S Singh, Bijoy Kundu, Philip Prathipati, Anil K Saxena, Dinesh K Dikshit, Leena Rastogi, Chetna Dixit, M B Gupta, G K Patnaik, Madhu Dikshit

Index: Eur. J. Med. Chem. 42 , 386-93, (2007)

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Abstract

In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of alpha-amino acids were screened for their in vitro H(+)/K(+) ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.