Journal of Applied Toxicology 1984-10-01

Comparative effects of various lead salts on delayed hypersensitivity in mice.

J Descotes, J C Evreux, A Laschi-Locquerie, P Tachon

Index: J. Appl. Toxicol. 4(5) , 265-6, (1984)

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Abstract

Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell-mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.