Journal of Surgical Research 2014-05-15

Effects of terlipressin on microcirculation of small bowel mesentery in rats with endotoxic shock

Xiaohua Qiu, Yanxia Huang, Jingyuan Xu, Haibo Qiu, Yi Yang

Index: J. Surg. Res. 188(2) , 503-9, (2014)

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Abstract

Background Septic shock is still related to unacceptably high morbidity and mortality. Microcirculatory alteration has been demonstrated to be one important reason associated with this evolution. Vasoactive drugs are often used to restore adequate arterial pressure and tissue perfusion in septic shock. To define the roles of different drugs, the effects of terlipressin (TP) on the microcirculation of small bowel mesentery in rats with endotoxic shock were evaluated and compared with those of norepinephrine (NE).