Norepinephrine

Potential Acute Health Effects Very hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant),
of inhalation. Severe over-exposure can result in death.
Potential Chronic Health EffectsCARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance is toxic to cardiovascular system.
The substance may be toxic to muscle tissue.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a
highly toxic material may produce general deterioration of health by an accumulation in one or many human
organs.

---

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Not available.
Serious Skin Contact
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Inhalation
Get medical attention.
Serious InhalationEvacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek medical attention.
IngestionIf swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
attention immediately.
Serious IngestionNot available.

---

Section 5. Fire and Explosion Data
Flammability of the ProductMay be combustible at high temperature.
Not available.
Auto-Ignition Temperature
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Products of Combustion
Slightly flammable to flammable in presence of heat.
Fire Hazards in Presence of
Various Substances
Explosion Hazards in Presence of Risks of explosion of the product in presence of mechanical impact: Not available.
Various SubstancesRisks of explosion of the product in presence of static discharge: Not available.
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Special Remarks on Explosion
explosion hazard.
Hazards
L-Norepinephrine

---

Section 6. Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Small Spill
Poisonous solid.
Large Spill
Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to
reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition

---

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
show the container or the label. Keep away from incompatibles such as oxidizing agents, acids, alkalis.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above -20°C (-4°F).
Storage
Freeze.

---

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure LimitsNot available.

---

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline solid. Crystalline powder.)Not available.
Odor
TasteNot available.
Molecular Weight169.18 g/mole
Off-white.
Color
Not available.
pH (1% soln/water)
Not available.
Boiling Point
Melting Point220°C (428°F)
Critical TemperatureNot available.
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Vapor DensityNot available.
Not available.
Volatility
Not available.
Odor Threshold
Water/Oil Dist. Coeff.Not available.
Ionicity (in Water)Not available.
Not available.
Dispersion Properties
Not available.
Solubility
L-Norepinephrine

---

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Conditions of InstabilityExcess heat, incompatible materials
Reactive with oxidizing agents, acids, alkalis.
Incompatibility with various
substances
Not available.
Corrosivity
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
PolymerizationWill not occur.

---

Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsAcute oral toxicity (LD50): 20 mg/kg [Mouse].
Chronic Effects on HumansMUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
Causes damage to the following organs: cardiovascular system.
May cause damage to the following organs: muscle tissue.
Other Toxic Effects on Humans Very hazardous in case of ingestion.
Slightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks onNot available.
Toxicity to Animals
Human: passes the placental barrier.
Special Remarks on
May cause adverse reproductive effects and birth defects (teratogenic).
Chronic Effects on Humans
May affect genetic material (mutagenic)
Acute Potential Health Effects:
Special Remarks on other Toxic
Skin: May cause skin irritation.
Effects on Humans
Eyes: May cause eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: May be fatal if swallowed. May cause nausea, vomiting, and hypersalivation. Affects the
cardiovascular system/heat (hypertension, dradycardia, arrhythmias, anginal pain, palpitations, cardiac arrest,
sudden death. May affect metabolism (altered glucose metabolism). May affect the blood (aggregated pltelets
and occlusive platelet thrombi), behavior/central nervous system (fear, anxiety, restlessness, tremor, insomnia,
somnolence, muscle weakness, confusion, irritability, weakness, psychosis), kidneys (nephrotoxicity), respiration
(dyspnea).

---

Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Products of Biodegradation
arise.
The products of degradation are less toxic than the product itself.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
L-Norepinephrine

---

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

---

Section 14. Transport Information
DOT ClassificationCLASS 6.1: Poisonous material.
UNNA: 2811 : Toxic solid, organic, n.o.s(L-Norepinephrine) PG: II
Identification
Not available.
Special Provisions for
Transport
DOT (Pictograms)

---

Section 15. Other Regulatory Information and Pictograms
Federal and StateNo products were found.
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Regulations
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
Other ClassificationsWHMIS (Canada)
DSCL (EEC)R28- Very toxic if swallowed.S28- After contact with skin, wash immediately
with plenty of water
S36/37- Wear suitable protective clothing and
gloves.
S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the
label where possible).
Health Hazard
HMIS (U.S.A.)3 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
3 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
L-Norepinephrine
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or equivalent.
Wear appropriate respirator when
ventilation is inadequate.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

MOLECULAR FORMULA :

C8-H11-N-O3

MOLECULAR WEIGHT :

169.20

WISWESSER LINE NOTATION :

Z1YQR CQ DQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

100 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

20 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

550 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

250 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

8 mg/kg

SEX/DURATION :

female 7-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

60 ug/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

16 mg/kg

SEX/DURATION :

female 7-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

10 ug/kg

SEX/DURATION :

female 63 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Vascular - measurement of regional blood flow Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

2 mg/kg

SEX/DURATION :

female 7-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - hepatobiliary system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

2 mg/kg

SEX/DURATION :

female 7-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :

5800 nmol/L

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1414,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1103 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 85 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1103 No. of Facilities: 68 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 613 (estimated) No. of Female Employees: 175 (estimated)