Carbohydrate Research 2009-07-27

Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis.

Qingchao Liu, Peng Wang, Lei Zhang, Tiantian Guo, Guokai Lv, Yingxia Li

Index: Carbohydr. Res. 344(11) , 1276-81, (2009)

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Abstract

The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.