Voprosy Meditsinskoi Khimi 1988-01-01

[Prevention of post-resuscitation impairment of energy metabolism in the myocardium using sodium gamma-hydroxybutyrate, ionol and gutimine].

V T Dolgikh

Index: Vopr. Med. Khim. 34(1) , 33-8, (1988)

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Abstract

Long-term impairments of energy metabolisms in myocardium were found in rats after clinical death caused by acute hemorrhage. Bioenergetics of myocardium tended to normalize within a month after resuscitation. Severity of postresuscitation period correlated with the level of deteriorations observed in energy metabolism. Preadministration of gamma-aminobutyric acid, ionol and gutimine decreased these impairments as well as the postresuscitation lethality. Considering the final results of resuscitation the efficiency of the drugs studied might be arranged in a following order: gamma-aminobutyric acid, ionol, gutimine.