Organic Letters 2010-10-01

Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.

Ying Wei, Jing Liu, Shaoxia Lin, Hongqian Ding, Fushun Liang, Baozhong Zhao

Index: Org. Lett. 12 , 4220-4223, (2010)

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Abstract

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines, a series of substituted aryl ureas were achieved in high yields. Acetoacetanilide substrates can be considered as masked reagents that liberate reactive isocyanates in situ.