2-Pipecoline
2-Pipecoline structure
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Common Name | 2-Pipecoline | ||
|---|---|---|---|---|
| CAS Number | 109-05-7 | Molecular Weight | 99.174 | |
| Density | 0.8±0.1 g/cm3 | Boiling Point | 118.8±0.0 °C at 760 mmHg | |
| Molecular Formula | C6H13N | Melting Point | -4--5 °C | |
| MSDS | Chinese USA | Flash Point | 8.3±0.0 °C | |
| Symbol |
GHS02, GHS05, GHS07 |
Signal Word | Danger | |
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C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation.
Chemistry 16 , 13063-13067, (2010)
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Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation.
Chem. Commun. (Camb.) 46 , 3351-3353, (2010) A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities. |
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Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.
Org. Lett. 12 , 4220-4223, (2010) A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines, a series of substituted aryl ureas were achieved in high ... |
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Synthesis of 2-aminobenzoxazoles using tetramethyl orthocarbonate or 1,1-dichlorodiphenoxymethane.
J. Org. Chem. 75 , 7942-7945, (2010) The synthesis of 2-aminobenzoxazoles can be readily achieved by two versatile, one-pot procedures utilizing commercially available tetramethyl orthocarbonate or 1,1-dichlorodiphenoxymethane, an amine, and an optionally substituted 2-aminophenol. The reactions... |
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Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity.
Bioorg. Med. Chem. 18 , 3812-3822, (2010) There is an urgent need to design and develop new and more potent EGFR inhibitors with improved anti-tumor activity. Here we describe the design and synthesis of two series of 4-benzothienyl amino quinazolines as new analogues of the EGFR inhibitor Gefitinib.... |
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Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists.
Bioorg. Med. Chem. Lett. 20 , 3669-3674, (2010) A novel series of [6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethyl]-dialkylamines was discovered as potent CRF(1)R antagonists. The optimization of binding affinity in the series by the parallel reaction approach is discussed herein.Cop... |
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Efficient solid-phase synthesis of sulfotyrosine peptides using a sulfate protecting-group strategy.
Angew. Chem. Int. Ed. Engl. 48(11) , 2024-6, (2009) Double protection: Efficient Fmoc-based solid-phase synthesis (SPPS) of sulfotyrosine (sY) peptides is achieved by incorporating the sY residue(s) as a dichlorovinyl-protected (DCV) sulfodiester(s) and using 2-methylpiperidine for Fmoc removal. After removal ... |
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Analysis of vibrational spectra of 2 and 3-methylpiperidine based on density functional theory calculations.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 74(1) , 162-7, (2009) The experimental and theoretical vibrational spectra of 2 and 3-methylpiperidine (abbreviated as 2-MP and 3-MP) were studied. The FT-Infrared spectra of 2-MP and 3-MP molecules were recorded in the liquid phase. The structural and spectroscopic analysis of th... |
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Opioid and nicotinic medullary hyperalgesic influences in the decerebrated rat.
Pharmacol. Biochem. Behav. 29(4) , 725-31, (1988) The effects of ethylketazocine (EKC) administered intraperitoneally and the nicotinic ligands (-)- and (+)-nicotine, (-)-cytisine, (-)-lobeline, and (+)-2-methylpiperidine administered into the 4th ventricle on the latency of the thermally evoked withdrawal r... |
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Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
J. Med. Chem. 28(9) , 1245-51, (1985) Previous studies have shown that (+/-)-[3H]nicotine binds to multiple sites in the rat brain P2 preparation. Using a series of pyridine, piperidine and pyrrolidine analogues, the present studies identified drugs with specificity for a separate up-regulatory s... |