Acta Medica Okayama 1990-02-01

Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.

Y Gomita, K Furuno, Y Araki

Index: Acta Med. Okayama 44(1) , 51-3, (1990)

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Abstract

The plasma level of isosorbide dinitrate intraperitoneally administered to rats stressed by foot-shock was almost the same as that in non-stressed control rats. However, levels of its metabolites, 5-isosorbide mononitrate and 2-isosorbide mononitrate, were lower in stressed rats than in non-stressed rats, suggesting that stress may influence the metabolism and/or excretion of the metabolites.