Ugeskrift for laeger 2013-02-11

[Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].

Emilie Øberg, Casper Claudius

Index: Ugeskr. Laeg. 175(7) , 428-32, (2013)

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Abstract

Neuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of sugammadex - an antidote to the NMB rocuronium - which within 1-3 minutes neutralizes the effects of rocuronium. High-dose rocuronium is now an alternative to suxamethonium in acute or short procedures and in a situation, where ventilation/intubating cannot be performed, sugammadex can reverse the rocuronium blockade within minutes.