Neostigmine Bromide
Neostigmine Bromide structure
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Common Name | Neostigmine Bromide | ||
|---|---|---|---|---|
| CAS Number | 114-80-7 | Molecular Weight | 303.195 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H19BrN2O2 | Melting Point | 175-177 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Revival of physostigmine - a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients.
Clin. Chem. Lab Med. 53 , 1259-64, (2015) Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physosti... |
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Microwave-assisted synthesis, molecular docking, and cholinesterase inhibitory activities of new ethanediamide and 2-butenediamide analogues.
Chem. Pharm. Bull. 63(3) , 210-7, (2015) A novel series of meta-substituted ethanediamide and 2-butenediamide derivatives were synthesized and tested for their ability to inhibit electric eel acetylcholinesterase (AChE) and equine serum butyrylcholinesterase (BuChE). The synthesized compounds were e... |
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Alterations in gills of Lepomis gibbosus, after acute exposure to several xenobiotics (pesticide, detergent and pharmaceuticals): morphometric and biochemical evaluation.
Drug Chem. Toxicol. 38 , 126-32, (2015) In recent decades, scientific research about the effects of anthropogenic xenobiotics on non-target organisms has increased. Among the likely effects, some studies reported the evaluation of biochemical and morphological changes in specific tissues or organs ... |
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In vivo and in vitro effects of neostigmine on gastrointestinal tract motility of horses.
Am. J. Vet. Res. 74(4) , 579-88, (2013) To determine the response to neostigmine of the contractile activity of the jejunum and pelvic flexure and the effects of a continuous rate infusion (CRI) of neostigmine in horses.7 adult horses and tissue from 12 adult horses.A CRI of neostigmine (0.008 mg/k... |
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An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.
J. Biomol. Screen. 18(1) , 108-15, (2013) Organophosphates are a class of highly toxic chemicals that includes many pesticides and chemical weapons. Exposure to organophosphates, either through accidents or acts of terrorism, poses a significant risk to human health and safety. Existing antidotes, in... |
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Global small bowel motility: assessment with dynamic MR imaging.
Radiology 269(2) , 443-50, (2013) To assess the repeatability in human volunteers of software-quantified small bowel motility captured with magnetic resonance (MR) imaging and to test the ability to detect changes in motility induced by pharmacologic agents.The study was approved by the Royal... |
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Impaired brain development and reduced cognitive function in phospholipase D-deficient mice.
Neurosci. Lett. 572 , 48-52, (2014) The phospholipases D (PLD1 and 2) are signaling enzymes that catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid, a lipid second messenger involved in cell proliferation, and choline, a precursor of acetylcholine (ACh). In the present study, w... |
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Premonitory signs and symptoms of envenoming by common krait (Bungarus caeruleus).
Trop. Doct. 44(2) , 82-5, (2014) Between January 2005 and August 2011 141 victims of krait bite poisoning were admitted to the general hospital at Mahad. Clinical signs and symptoms preceding the development of neuroparalysis were analyzed. Fifty-six percent of patients were male. A total of... |
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[Anticholinesterases; peripheral and central effects].
Masui. 62(1) , 19-26, (2013) Anticholinesterase, such as neostigmine, was used to be a standard drug at the end of surgery for reversal of nondepolarizing neuromuscular block. Neostigmine decreases the metabolism of acetylcholine (ACh) at the neuromuscular junction and allows its concent... |
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[Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].
Ugeskr. Laeg. 175(7) , 428-32, (2013) Neuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of... |