Journal of Peptide Science 2007-10-01

Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2.

Panagiota Moutevelis-Minakakis, Afroditi Neokosmidi, Maria Filippakou, Daren Stephens, Edward A Dennis, George Kokotos

Index: J. Pept. Sci. 13 , 634-641, (2007)

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Abstract

A variety of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues were synthesized. 2-oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA(2), while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA(2).Copyright (c) 2007 European Peptide Society and John Wiley & Sons, Ltd.