Metal??Free Michael??Addition??Initiated Three??Component Reaction for the Regioselective Synthesis of Highly Functionalized Pyridines: Scope, Mechanistic …

…, J Rodriguez, T Constantieux

Index: Allais, Christophe; Lieby-Muller, Frederic; Rodriguez, Jean; Constantieux, Thierry European Journal of Organic Chemistry, 2013 , # 19 p. 4131 - 4145

Full Text: HTML

Citation Number: 15

Abstract

Abstract A metal-free and completely regioselective three-component synthesis of highly functionalized pyridines from 1, 3-dicarbonyl derivatives and Michael acceptors has been achieved. Activated Michael acceptors, that is, β, γ-unsaturated α-oxo carbonyl derivatives, were utilized, allowing substitution at the 4-position and remarkable functional diversity at the 2-position of the pyridine ring. The scope and limitations of this environmentally ...