Ligand??Free Copper??Catalyzed Amination of Heteroaryl Halides with Alkyl??and Arylamines

…, JP Vors, ERF Gesing, C Bolm

Index: Liu, Zhen-Jiang; Vors, Jean-Pierre; Gesing, Ernst R. F.; Bolm, Carsten Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3158 - 3162

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Citation Number: 27

Abstract

Heteroaromatic compounds are ubiquitous in natural products and biologically active molecules.1 Among them, aminopyridines and aminopyrimidines are of great interest in the fine chemical industry owing to their importance as intermediates for pharmaceuticals,2a–e agrochemicals2f,g and materials.2h–j Traditional preparations of such compounds involve nucleophilic aromatic substitutions of pyridine or pyrimidine halides, but those methods suffer from a ...

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