Journal of Organic Chemistry 2006-12-08

An efficient base-free N-arylation of imidazoles and amines with arylboronic acids using copper-exchanged fluorapatite.

M Lakshmi Kantam, Gopaldasu T Venkanna, Chidara Sridhar, Bojja Sreedhar, Boyapati M Choudary

Index: J. Org. Chem. 71 , 9522, (2006)

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Abstract

N-Arylation of imidazoles and amines with arylboronic acids was accomplished with copper-exchanged fluorapatite (CuFAP) in methanol at room temperature. The products N-arylimidazoles and N-arylamines were isolated in good to excellent yields. A variety of arylboronic acids were converted to the corresponding N-arylimidazoles and N-arylamines, demonstrating the versatility of the reaction.