Bulletin of Experimental Biology and Medicine 2011-12-01

Structural characteristics of renal glomerular system in ISIAH rats under conditions of chronic stress and preventive hypotensive drug therapy.

E E Filyushina, M D Shmerling, V A Lazarev, I I Buzueva, A L Merkel, G S Yakobson

Index: Bull. Exp. Biol. Med. 152(2) , 249-52, (2011)

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Abstract

The effects of chronic stress on the structure and function of the renal glomerular system were studied in hypertensive ISIAH rats treated with hypotensive drugs during the early ontogeny. The morphometric parameters of the renal glomerular system, characteristic of each of the experimental animal groups treated by enalapril, losartan, or terazosin in early age virtually did not change under conditions of stress exposure. These results indicate a persistent delayed nephroprotective effect of these drugs.