Terazosin

Terazosin Structure
Terazosin structure
Common Name Terazosin
CAS Number 63590-64-7 Molecular Weight 387.43300
Density 1.332 g/cm3 Boiling Point 664.5ºC at 760 mmHg
Molecular Formula C19H25N5O4 Melting Point 281-283°C
MSDS Chinese USA Flash Point 355.7ºC
Symbol GHS07
GHS07
Signal Word Warning

Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus.

J. Physiol. 592(Pt 16) , 3597-609, (2014)

Noradrenergic neurotransmission in the brainstem is closely coupled to changes in muscle activity across the sleep-wake cycle, and noradrenaline is considered to be a key excitatory neuromodulator that reinforces the arousal-related stimulus on motoneurons to...

Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.

J. Pharm. Biomed. Anal. 111 , 333-43, (2015)

Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both analytically and on a preparative scale. The use of SFC as a...

Efficacy of three different alpha 1-adrenergic blockers and hyoscine N-butylbromide for distal ureteral stones.

Int. Braz J Urol 37(2) , 195-200; discussion 201-2, (2011)

To evaluate hyoscine N-butyl bromide (HBB) and three different alpha-1 blockers in the treatment of distal ureteral stones.A total of 140 patients with stones located in the distal tract of the ureter with stone diameters of 5 to 10mm were enrolled in the pre...

Multiple cerebral infarctions related to famotidine-induced eosinophilia.

J. Neurol. 259(10) , 2229-31, (2012)

Pharmacologic pupil dilation as a predictive test for the risk for intraoperative floppy-iris syndrome.

J. Cataract Refract. Surg. 37(8) , 1447-54, (2011)

To evaluate the effect of α1-adrenergic receptor antagonists (α1-ARAs) on pupil diameter and determine whether the diameter predicts intraoperative floppy-iris syndrome (IFIS).Ophthalmology Section, Palermo University, Palermo, Italy.Prospective cohort study....

[How effective is finasteride?].

Dtsch. Med. Wochenschr. 136(8) , 354, (2011)

Terazosin activates Pgk1 and Hsp90 to promote stress resistance.

Nat. Chem. Biol. 11(1) , 19-25, (2015)

Drugs that can protect against organ damage are urgently needed, especially for diseases such as sepsis and brain stroke. We discovered that terazosin (TZ), a widely marketed α1-adrenergic receptor antagonist, alleviated organ damage and improved survival in ...

[Efficacy of compound Xuanju capsule in the treatment of chronic prostatitis with erectile dysfunction].

Zhonghua Nan Ke Xue 18(10) , 950-2, (2012)

To evaluate the efficacy and safety of Compound Xuanju Capsule (CXC) in the treatment of chronic prostatitis with erectile dysfunction (ED).We obtained NIH-CPSI and IIEF-5 scores from 132 chronic prostatitis patients with ED and divided the patients into a co...

An alpha1-adrenoceptor blocker terazosin improves urine storage function in the spinal cord in spinal cord injured rats.

Life Sci. 92(2) , 125-30, (2013)

To confirm the role of alpha1-adrenoceptor (α(1)-AR) in the spinal cord, we investigated the effect of intrathecal application of terazosin, a non-selective α(1)-AR blocker, on the micturition reflex, as well as the change of α(1)-AR subtypes mRNA in the lumb...

Effect of terazosin on sweating in patients with major depressive disorder receiving sertraline: a randomized controlled trial.

Int. J. Psychiatry Clin. Pract. 17(1) , 44-7, (2013)

By considering the role of adrenergic nervous system in sweat secretion, we postulated that terazosin may be able to improve sweating after taking sertraline, a selective serotonin reuptake inhibitor (SSRI) drug. This study was designed to evaluate the effect...