Nickel??Catalyzed C H Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules

…, M Komiyama, J Canivet, J Yamaguchi…

Index: Yamamoto, Takuya; Muto, Kei; Komiyama, Masato; Canivet, Jerome; Yamaguchi, Junichiro; Itami, Kenichiro Chemistry - A European Journal, 2011 , vol. 17, # 36 p. 10113 - 10122

Full Text: HTML

Citation Number: 111

Abstract

Abstract Novel nickel-based catalytic systems for the C [BOND] H arylation of azoles with haloarenes and aryl triflates have been developed. We have established that Ni (OAc) 2/bipy/LiOtBu serves as a general catalytic system for the coupling with aryl bromides and iodides as aryl electrophiles. For couplings with more challenging electrophiles, such as aryl chlorides and triflates, the Ni (OAc) 2/dppf (dppf= 1, 1′-bis (diphenylphosphino) ...