Photo??Cross??Coupling Reaction of Electron??Rich Aryl Chlorides and Aryl Esters with Alkynes: A Metal??Free Alkynylation

S Protti, M Fagnoni, A Albini

Index: De Carolis, Marco; Protti, Stefano; Fagnoni, Maurizio; Albini, Angelo Angewandte Chemie - International Edition, 2005 , vol. 44, # 8 p. 1232 - 1236

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Citation Number: 68

Abstract

Aryl acetylenes are versatile intermediates in organic synthesis in view of the easy derivatization of their triple bonds [1] and find application in molecular electronics.[2] The elective method for the synthesis of these compounds is the Sonogashira reaction, which involves the Pd/Cu-mediated formation of a C (sp2) ÀC (sp) bond. Despite many efforts to improve this method, the most popular protocol in use today still consists of a mixture of an ...