Estragole

Modify Date: 2024-01-03 22:38:56

Estragole structure	Common Name	Estragole
	CAS Number	140-67-0	Molecular Weight	148.202
	Density	0.9±0.1 g/cm3	Boiling Point	216.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	81.1±0.0 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Estragole

Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole has potent local anesthetic activity and dose-dependently blocks nerve excitability[1]. Estragole displays anti-toxoplasma activity[2].

Name	4-Allylanisole
Synonym	More Synonyms

Description	Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole has potent local anesthetic activity and dose-dependently blocks nerve excitability[1]. Estragole displays anti-toxoplasma activity[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Leal-Cardoso JH, et al. Effects of estragole on the compound action potential of the rat sciatic nerve. Braz J Med Biol Res. 2004 Aug;37(8):1193-8. [2]. Oliveira CB, et al. Anti-Toxoplasma Activity of Estragole and Thymol in Murine Models of Congenital and Noncongenital Toxoplasmosis. J Parasitol. 2016 Jun;102(3):369-76.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Leal-Cardoso JH, et al. Effects of estragole on the compound action potential of the rat sciatic nerve. Braz J Med Biol Res. 2004 Aug;37(8):1193-8.

[2]. Oliveira CB, et al. Anti-Toxoplasma Activity of Estragole and Thymol in Murine Models of Congenital and Noncongenital Toxoplasmosis. J Parasitol. 2016 Jun;102(3):369-76.

Density	0.9±0.1 g/cm3
Boiling Point	216.0±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₂O
Molecular Weight	148.202
Flash Point	81.1±0.0 °C
Exact Mass	148.088821
PSA	9.23000
LogP	3.15
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.505
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.

Estragole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8225000

CHEMICAL NAME :: Anisole, p-allyl-

CAS REGISTRY NUMBER :: 140-67-0

BEILSTEIN REFERENCE NO. :: 1099454

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C10-H12-O

MOLECULAR WEIGHT :: 148.22

WISWESSER LINE NOTATION :: 1U2R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1030 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97 gm/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 111 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg/22D-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 195 gm/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Liver - angiosarcoma

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5058 No. of Facilities: 668 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 9128 (estimated) No. of Female Employees: 6777 (estimated)

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H317-H341-H351
Precautionary Statements	P280
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S26-S36/37
RIDADR	NA 1993 / PGIII
WGK Germany	3
RTECS	BZ8225000
HS Code	2909309090

Precursor 10
CAS#:104-92-7 4-Bromoanisole CAS#:106-95-6 allyl bromide CAS#:623-12-1 1-Chloro-4-meth... CAS#:24850-33-7 Allyltributyltin
CAS#:591-87-7 Allyl acetate CAS#:696-62-8 4-Iodoanisole CAS#:1092390-58-3 sodium 1,1-dime... CAS#:107-05-1 ALLYL CHLORIDE
CAS#:762-72-1 Allyltrimethylsilane CAS#:15183-74-1 1-METHOXY-4-TRI...
DownStream 10
CAS#:4521-28-2 4-(4-Methoxyphe... CAS#:100-09-4 p-Anisic acid CAS#:104-01-8 4-Methoxyphenyl... CAS#:104-45-0 4-n-propylanisole
CAS#:5462-06-6 3-(4-methoxyphe... CAS#:56047-51-9 4-(4-Methoxyphe... CAS#:4180-23-8 trans-Anethole CAS#:25679-28-1 (Z)-anethol
CAS#:501-92-8 p-Allylphenol CAS#:20637-08-5 Methyl 4-(4-met...

HS Code	2909309090
Summary	2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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4-allyl-1-methoxybenzene

Anisole, p-allyl-

p-Allyl-Anisole

Tarragon

4-allyl

Estragol

1-Methoxy-4-(2-propen-1-yl)benzene

Estragole

4-Methoxyallylbenzene

Chavicol methyl ether,Estragole

4-MeOC6H4CH2-CH=CH2

Esdragon

methyl chavicol

p-methoxyallylbenzene

Benzene, 1-methoxy-4-(2-propen-1-yl)-

4-Allylmethoxybenzene

para-allylanisole

Terragon

FEMA 2411

Esdragol

4-Allylphenyl methyl ether

EINECS 205-427-8

Chavicol methyl ether

Chavicol, O-methyl-

1-Allyl-4-methoxybenzene

1-Methoxy-4-(2-propenyl)benzene

1U2R DO1

4-Allylanisole

Esdragole

MFCD00008653

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Estragole
Price: ￥248.0/25ml ￥658.0/100mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Zhejiang Hangyu API Co., Ltd
China
Product Name: 4-Allylanisole
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Allylanisole
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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