Journal of Antibiotics 1986-08-01

K-252a, a potent inhibitor of protein kinase C from microbial origin.

H Kase, K Iwahashi, Y Matsuda

Index: J. Antibiot. 39 , 1059, (1986)

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Abstract

K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.