K-252a
K-252a structure
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Common Name | K-252a | ||
|---|---|---|---|---|
| CAS Number | 99533-80-9 | Molecular Weight | 467.473 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 685.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H21N3O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 368.2±31.5 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Rat BMSCs initiate retinal endogenous repair through NGF/TrkA signaling.
Exp. Eye Res. 132 , 34-47, (2015) Müller cells can completely repair retinal injury by acting as endogenous stem/progenitor cells in lower-order vertebrates. However, a safe and effective approach to activate progenitor potential of retinal Müller cells in higher-order vertebrates, which rare... |
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HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells.
J. Virol. 88(22) , 13482-94, (2014) Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survival, and plasticity. These effects occur through autocrine and paracrine signaling events initiated by interactions between secreted BDNF and its high-affini... |
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Dopamine-sensitive signaling mediators modulate psychostimulant-induced ultrasonic vocalization behavior in rats.
Behav. Brain Res. 296 , 1-6, (2015) The mesolimbic dopamine system plays a major role in psychostimulant-induced ultrasonic vocalization (USV) behavior in rodents. Within this system, psychostimulants elevate synaptic concentrations of dopamine thereby leading to exaggerated activation of posts... |
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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proc. Natl. Acad. Sci. U. S. A. 104 , 20523-8, (2007) Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhibitors ha... |
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K-252a, a novel microbial product, inhibits smooth muscle myosin light chain kinase.
J. Biol. Chem. 263 , 6215-6219, (1988) Effects of K-252a, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8, 11-epoxy-1H,8H,11H-2,7b,11a-triazadibenzo[a,g]cycloocta [cde]trinden-1-one, purified from the culture broth of Nocardiopsis sp., on the activity of myosin ligh... |
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K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells.
J. Neurosci. 8 , 715-721, (1988) K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth factor (NGF) on PC 12 cells. At a concentration of 200 nM, K-252a prevents neurite generation initiated by NGF, but not neurite ge... |
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Inhibition of actin-myosin-ATP interaction of smooth muscle native actomyosin is not closely associated with inhibition of its myosin light chain phosphorylation: studies with derivatives of antibiotic SF-2370.
Prog. Clin. Biol. Res. 315 , 460-2, (1989)
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A new antibiotic SF-2370 produced by Actinomadura.
J. Antibiot. 38(10) , 1437-9, (1985)
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K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model.
J. Invest. Dermatol. 122 , 812-819, (2004) The peripheral nervous system, in addition to its sensory and motor functions, can induce a local inflammatory response known as neurogenic inflammation. This phenomenon plays a critical role in several inflammatory diseases, e.g., asthma, atopy, rheumatoid a... |
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K-252a, a potent inhibitor of protein kinase C from microbial origin.
J. Antibiot. 39 , 1059, (1986) K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM. |