K-252a

Modify Date: 2025-08-25 19:02:18

K-252a structure	Common Name	K-252a
	CAS Number	99533-80-9	Molecular Weight	467.473
	Density	1.7±0.1 g/cm3	Boiling Point	685.3±55.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₁N₃O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	368.2±31.5 °C
	Symbol	GHS08	Signal Word	Danger

Use of K-252a

K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2].

Name	K-252a
Synonym	More Synonyms

Description	K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> TGF-beta/Smad >> PKC
Target	IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2].
References	[1]. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). [2]. Davis, P.D., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides Journal of Medicinal Chemistry 35, 177-184 (1992).

Density	1.7±0.1 g/cm3
Boiling Point	685.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₁N₃O₅
Molecular Weight	467.473
Flash Point	368.2±31.5 °C
Exact Mass	467.148132
PSA	94.72000
LogP	4.23
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.841

K-252a MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KC6500000

CAS REGISTRY NUMBER :: 99533-80-9

LAST UPDATED :: 199212

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H21-N3-O5

MOLECULAR WEIGHT :: 467.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1437,1985

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360D-H371
Precautionary Statements	P201-P260-P308 + P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
RTECS	NZ0550000

Precursor 7
CAS#:77-78-1 Dimethyl sulfate CAS#:99570-78-2 K252b CAS#:111359-05-8 (5S,8R)-5-methy... CAS#:244128-11-8 13-((2R,4S,5S)-...
CAS#:236113-24-9 13-((2R,4S,5R)-... CAS#:244128-15-2 (3S,5R)-2-methy... CAS#:244128-17-4 (5S,6S,8R)-5-me...
DownStream 2
CAS#:111358-88-4 Lestaurtinib CAS#:126643-37-6 KT5823

Rat BMSCs initiate retinal endogenous repair through NGF/TrkA signaling.

Exp. Eye Res. 132 , 34-47, (2015)

Müller cells can completely repair retinal injury by acting as endogenous stem/progenitor cells in lower-order vertebrates. However, a safe and effective approach to activate progenitor potential of r...

HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells.

J. Virol. 88(22) , 13482-94, (2014)

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survival, and plasticity. These effects occur through autocrine and paracrine signaling events initiate...

Dopamine-sensitive signaling mediators modulate psychostimulant-induced ultrasonic vocalization behavior in rats.

Behav. Brain Res. 296 , 1-6, (2015)

The mesolimbic dopamine system plays a major role in psychostimulant-induced ultrasonic vocalization (USV) behavior in rodents. Within this system, psychostimulants elevate synaptic concentrations of ...

antibiotick252a

PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.

PROTEIN KINASE INHIBITOR K-252A

PROTEIN KINASE INHIBITOR

K252a

K-252A,NOCARDIOPSIS SP

K-252a

Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1.0.0.0.0.0]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate

6,9-Epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-7-carboxylic acid, 6,7,8,9,16,17-hexahydro-7-hydroxy-6-methyl-15-oxo-, methyl ester, (6S,7R,9R)-

antibioticsf2370

sf2370

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: K-252a
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: K252a
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: K252a
Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

K-252a suppliers

K-252a price

K-252a

Use of K-252a

Names

K-252a Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Articles19

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.