K-252a

Modify Date: 2024-01-03 11:35:11

K-252a structure	Common Name	K-252a
	CAS Number	99533-80-9	Molecular Weight	467.473
	Density	1.7±0.1 g/cm3	Boiling Point	685.3±55.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₁N₃O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	368.2±31.5 °C
	Symbol	GHS08	Signal Word	Danger

Use of K-252a

K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2].

Name	K-252a
Synonym	More Synonyms

Description	K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> TGF-beta/Smad >> PKC
Target	IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2].
References	[1]. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). [2]. Davis, P.D., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides Journal of Medicinal Chemistry 35, 177-184 (1992).

Density	1.7±0.1 g/cm3
Boiling Point	685.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₁N₃O₅
Molecular Weight	467.473
Flash Point	368.2±31.5 °C
Exact Mass	467.148132
PSA	94.72000
LogP	4.23
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.841

K-252a MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KC6500000

CAS REGISTRY NUMBER :: 99533-80-9

LAST UPDATED :: 199212

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H21-N3-O5

MOLECULAR WEIGHT :: 467.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1437,1985

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360D-H371
Precautionary Statements	P201-P260-P308 + P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
RTECS	NZ0550000

Precursor 7
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DownStream 2
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antibiotick252a

PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.

PROTEIN KINASE INHIBITOR K-252A

PROTEIN KINASE INHIBITOR

K252a

K-252A,NOCARDIOPSIS SP

K-252a

Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1.0.0.0.0.0]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate

6,9-Epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-7-carboxylic acid, 6,7,8,9,16,17-hexahydro-7-hydroxy-6-methyl-15-oxo-, methyl ester, (6S,7R,9R)-

antibioticsf2370

sf2370

DC Chemicals Limited
China
Product Name: K252a
Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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K-252a

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