Phase transfer catalysed N-substitution of 2H-1, 2-benzisothiazolin-3-one 1, 1-dioxide

J Svoboda, J Paleček, V Dědek

Index: Svoboda, Jiri; Palecek, Jaroslav; Dedek, Vaclav Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1304 - 1310

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Citation Number: 8

Abstract

N-Substituted derivatives of 2H-1,2-benzisothiazolin-3-one l,l-dioxide possess in- teresting biological properties1- 5 and they are often used as intermediates in the synthesis of antiinflammatory drugs on the basis of the so-called oxicams6 - 8. A number of examples of the preparation of compounds of this type are described in literature, based on the alkylation of alkali salts of 2H-1,2-benzisothiazolin -3-one l,I-dioxide, either without using solvents9 - 14 or in various solvents such as aceto- ...