Phenoxyethanol

Modify Date: 2024-01-01 19:38:02

Phenoxyethanol Structure
Phenoxyethanol structure
 Common Name Phenoxyethanol
CAS Number 122-99-6 Molecular Weight 138.164
Density 1.1±0.1 g/cm3 Boiling Point 245.2±0.0 °C at 760 mmHg
Molecular Formula C8H10O2 Melting Point 11-13 °C
MSDS Chinese USA Flash Point 105.3±14.1 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Phenoxyethanol


Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[1].

 Names

Name 2-phenoxyethanol
Synonym More Synonyms

 Phenoxyethanol Biological Activity

Description Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[1].
Related Catalog
References

[1]. B Dréno, et al. Safety Review of Phenoxyethanol When Used as a Preservative in Cosmetics. J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:15-24.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 245.2±0.0 °C at 760 mmHg
Melting Point 11-13 °C
Molecular Formula C8H10O2
Molecular Weight 138.164
Flash Point 105.3±14.1 °C
Exact Mass 138.068085
PSA 29.46000
LogP 1.16
Vapour density 4.8 (vs air)
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.526
Storage condition room temp
Water Solubility 30 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM0350000
CHEMICAL NAME :
Ethanol, 2-phenoxy-
CAS REGISTRY NUMBER :
122-99-6
BEILSTEIN REFERENCE NO. :
1364011
LAST UPDATED :
199710
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C8-H10-O2
MOLECULAR WEIGHT :
138.18
WISWESSER LINE NOTATION :
Q2OR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1260 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14422 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
554 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
933 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
182 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17500 mg/kg/14D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Blood - other changes Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/m3/9W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Liver - liver function tests impaired
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3 gm/kg/10D-I
TOXIC EFFECTS :
Behavioral - general anesthetic Kidney, Ureter, Bladder - other changes in urine composition Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
14 gm/kg/14D-I
TOXIC EFFECTS :
Blood - other changes Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
2000 ppm
REFERENCE :
MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 28,7,1980 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83449 No. of Facilities: 711 (estimated) No. of Industries: 18 No. of Occupations: 19 No. of Employees: 9560 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83449 No. of Facilities: 5523 (estimated) No. of Industries: 63 No. of Occupations: 77 No. of Employees: 111040 (estimated) No. of Female Employees: 46637 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R22;R36
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS KM0350000
HS Code 29094990

 Synthetic Route

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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 Synonyms

Phenoxytol
MFCD00046644
Ethylene glycol monophenyl ether
PHENOXETOL
PHENOXYETHYL ALCOHOL
Phenylglycol
emery6705
Dowanol EP
2-hydroxyethyl phenyl ether
dowanoleph
phenoxy ethanol
2-Phenoxyethanol
2-phenyloxyethanol
EINECS 204-589-7
2-phenoxyethan-1-ol
Arosol
Phenyl cellosolve
Rose ether
Ethylene glycol monophenyl ether,PHE-G,PHE-S
Ethanol, 2-phenoxy-
1-Hydroxy-2-phenoxyethane
2-Phenoxy-ethanol
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Chemsrc provides Phenoxyethanol(CAS#:122-99-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Phenoxyethanol are included as well.>> amp version: Phenoxyethanol

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