Organic Letters 2006-11-09

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

Marcus Baumann, Ian R Baxendale, Steven V Ley, Christoper D Smith, Geoffrey K Tranmer

Index: Org. Lett. 8 , 5231, (2006)

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Abstract

[Structure: see text] A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.