Ethyl isocyanoacetate

Ethyl isocyanoacetate Structure
Ethyl isocyanoacetate structure
Common Name Ethyl isocyanoacetate
CAS Number 2999-46-4 Molecular Weight 113.115
Density 1.035 g/mL at 25 °C(lit.) Boiling Point 194-196 °C(lit.)
Molecular Formula C5H7NO2 Melting Point 194-196ºC
MSDS Chinese USA Flash Point 184 °F
Symbol GHS07
GHS07
Signal Word Warning

Synthesis of imidazoles through the copper-catalyzed cross-cycloaddition between two different isocyanides.

J. Am. Chem. Soc. 128 , 10662, (2006)

The copper-catalyzed reaction between two different isocyanides produces the corresponding heteroaromatization products, imidazoles, in good yields. The reaction proceeds most probably through the activation of the sp3 C-H bond in the isocyanides by a copper ...

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

Org. Lett. 8 , 5231, (2006)

[Structure: see text] A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The ...

Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

J. Med. Chem. 36 , 1001, (1993)

A series of imidazo[1,5-a][1,4]benzodiazepine esters have been synthesized with varying ester side chains and 8-position substituents. The affinities of these compounds were evaluated at both "diazepam-insensitive" (DI) and diazepam-sensitive (DS) subtypes of...

Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles.

Chem. Commun. (Camb.) 48(100) , 12228-30, (2012)

A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is propose...

Tetrahedron Lett. 35 , 2493, (1994)

Tetrahedron Lett. 34 , 5463, (1993)

Tetrahedron Lett. 47 , 5481, (2006)